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20230404-tissue-chip.jpeg
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Title
Two photos of tissue chips. The one on the left shows mini-kidneys with homozygous PKD mutations, the one on the right shows gene-corrected heterozygotes.
Caption
Scientists would like to know how cysts form in polycystic kidney disease (PKD). Here, they compared two 3-D mini-kidney models. On the left, a model shows a mini kidney with a gene mutation that causes cysts to form. On the right, researchers used gene editing to correct a gene mutation, preventing the development of cysts.
Credit
Vishy, et al., Cell Stem Cell 2024
Description
Caption: Scientists would like to know how cysts form in polycystic kidney disease (PKD). Here, they compared two 3-D mini-kidney models. On the left, a model shows a mini kidney with a gene mutation that causes cysts to form. On the right, researchers used gene editing to correct a gene mutation, preventing the development of cysts.
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Alt Text
Two photos of tissue chips. The one on the left shows mini-kidneys with homozygous PKD mutations, the one on the right shows gene-corrected heterozygotes.